ARTICANZ - Beta (ver 0.91)
Annotated Registry of Trials in Cancer, Australia and New Zealand Ed.
- Results - target/PRMT5-inhibitor-MTA-co-operative
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ARTICANZ provides informational content about cancer drug trials in Australia/NZ that is updated weekly but may not be completely accurate, and should not replace medical advice from qualified healthcare professionals. The platform is intended to be useful, providing information "as is" without warranties. Non-medical users must always consult healthcare providers for all clinical decisions.
Search results
target/PRMT5-inhibitor-MTA-co-operative
8
trial(s) found.
NCT07063745
Advanced
Phase 2 / Phase 3
Recruiting
A Randomized Phase 2/3 Study of Navlimetostat (BMS-986504) in Combination With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion (
MountainTAP-29
)
PRMT5 inhibitor,MTA-co-operative
anti-PD-1 monoclonal antibody
placebo
Non-small cell lung cancer
NSW
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital
2170 - Liverpool - Liverpool Hospital
ACT
2605 - Garran - The Canberra Hospital
VIC
3350 - Ballarat - Grampians Health Service's Ballarat Base Hospital
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
4575 - Birtinya - Sunshine Coast University Hospital
SA
5112 - Elizabeth Vale - Lyell McEwin Hospital
TAS
7000 - Hobart - Royal Hobart Hospital
NCT06973863
Advanced
Phase 1
Recruiting
A Phase 1a/1b Study Evaluating the Clinical Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Efficacy of PEP08 as Monotherapy and Combination Therapy in MTAP-Del Advanced or Metastatic Solid Tumors (
PEP08-101
)
PRMT5 inhibitor,MTA-co-operative
MTAP:deletion
NOT Sarcoma
Solid tumour
NSW
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital
SA
5011 - Woodville South - The Queen Elizabeth Hospital
NCT06855771
Advanced
Phase 2
Recruiting
A Multicenter, Randomized, Open-label, Phase 2 Study Evaluating the Safety and Efficacy of Navlimetostat (BMS-986504) Monotherapy in Participants With Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion After Progression on Prior Therapies (
CA240-0009
)
PRMT5 inhibitor,MTA-co-operative
Non-small cell lung cancer
NSW
2050 - Camperdown - Chris O'Brien Lifehouse
2560 - Campbelltown - GenesisCare Campbelltown
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
NCT06589596
Advanced
Phase 1
Recruiting
A Phase 1a/b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of PRMT5 Inhibitor BGB-58067 Alone and in Combination With Anticancer Agents in Patients With Advanced Solid Tumors (
BGB-58067-101
)
PRMT5 inhibitor,MTA-co-operative
Non-small cell lung cancer
Pancreatic adenocarcinoma
NSW
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre
VIC
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre
3168 - Clayton - Monash Medical Centre
QLD
4102 - Woolloongabba - Princess Alexandra Hospital
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT06137144
Paed
Phase 1 / Phase 2
Recruiting
A Modular Phase I/II, Open-label, Multicentre Study to Evaluate the Safety, Tolerability, and Efficacy of AZD3470, a PRMT5 Inhibitor, as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies (
PRIMAVERA
)
PRMT5 inhibitor
PRMT5 inhibitor,MTA-co-operative
Lymphoma
Non-Hodgkin's lymphoma
Peripheral T-cell lymphoma
NSW
2298 - Waratah - Calvary Mater Newcastle Medical Oncology
VIC
3065 - Fitzroy - St Vincent's Hospital Melbourne
QLD
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre
4575 - Birtinya - Sunshine Coast University Hospital
SA
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre
WA
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre
NCT06130553
Advanced
Phase 1 / Phase 2
Recruiting
PRIMROSE
: A Modular Phase I/IIa, Multi-centre, Dose Escalation, and Expansion Study of AZD3470, a MTA Cooperative PRMT5 Inhibitor, as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced/Metastatic Solid Tumors That Are MTAP Deficient
PRMT5 inhibitor
PRMT5 inhibitor,MTA-co-operative
Solid tumour
VIC
3000 - Melbourne - Peter MacCallum Cancer Centre
NCT05975073
Advanced
Phase 1 / Phase 2
cohorts full
A Phase 1/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of Anvumetostat in Combination With IDE397 in Subjects With Advanced MTAP-null Solid Tumors
MAT2A inhibitor
PRMT5 inhibitor,MTA-co-operative
Non-small cell lung cancer
Solid tumour
VIC
3168 - Clayton - Monash Medical Centre
SA
5011 - Woodville South - The Queen Elizabeth Hospital
NCT07076121
Advanced
Phase 2 / Phase 3
Active not recruiting
A Randomized, Phase 2/3 Study Comparing Navlimetostat (BMS-986504) in Combination With Nab-paclitaxel and Gemcitabine Versus Placebo in Combination With Nab-paclitaxel and Gemcitabine in Participants With Untreated Metastatic Pancreatic Ductal Adenocarcinoma Harboring Homozygous MTAP Deletion (
CA240-0030
)
PRMT5 inhibitor,MTA-co-operative
antimetabolite
placebo
taxane
Pancreatic adenocarcinoma
NSW
2065 - St Leonards - GenesisCare North Shore Private Hospital
VIC
3066 - Epping - Northern Hospital
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre
QLD
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre
4102 - Woolloongabba - Princess Alexandra Hospital
SA
5011 - Woodville South - The Queen Elizabeth Hospital
WA
6150 - Murdoch - Fiona Stanley Hospital
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Recruitment Status
Recruiting (6)
cohorts full (1)
Active not recruiting (1)
Recruitment Country and State
NSW (6)
SA (6)
VIC (6)
QLD (5)
WA (3)
ACT (1)
TAS (1)
Phase
Phase 1 (2)
Phase 1 / Phase 2 (3)
Phase 2 (1)
Phase 2 / Phase 3 (2)
Trial Type
Advanced (7)
Paed (1)
Cancer Therapy Class
PRMT5
100%
PD-1
25%
PD-1/PD-L1
25%
MAT2A
25%
Trop2
13%
Facility
4102 - Woolloongabba - Princess Alexandra Hospital (4)
5011 - Woodville South - The Queen Elizabeth Hospital (3)
4575 - Birtinya - Sunshine Coast University Hospital (2)
5000 - Adelaide - Royal Adelaide Hospital - Adelaide Cancer Centre (2)
3168 - Clayton - Monash Medical Centre (2)
6009 - Nedlands - Sir Charles Gairdner Hospital - WA Cancer Centre (2)
2065 - St Leonards - Northern Sydney Cancer Centre, Royal North Shore Hospital (1)
2170 - Liverpool - Liverpool Hospital (1)
2605 - Garran - The Canberra Hospital (1)
3350 - Ballarat - Grampians Health Service's Ballarat Base Hospital (1)
5112 - Elizabeth Vale - Lyell McEwin Hospital (1)
7000 - Hobart - Royal Hobart Hospital (1)
2145 - Westmead - The Crown Princess Mary Cancer Centre - Westmead Hospital (1)
2050 - Camperdown - Chris O'Brien Lifehouse (1)
2560 - Campbelltown - GenesisCare Campbelltown (1)
2148 - Blacktown - Blacktown Hospital, Blacktown Cancer and Haematology Centre (1)
3084 - Heidelberg - Austin Hospital Olivia Newton-John Cancer Centre (1)
2298 - Waratah - Calvary Mater Newcastle Medical Oncology (1)
3065 - Fitzroy - St Vincent's Hospital Melbourne (1)
4101 - South Brisbane - Mater Hospital Brisbane / ICON Cancer Centre (1)
3000 - Melbourne - Peter MacCallum Cancer Centre (1)
2065 - St Leonards - GenesisCare North Shore Private Hospital (1)
3066 - Epping - Northern Hospital (1)
3144 - Malvern - Cabrini Health, Cabrini Cancer Care Centre (1)
4006 - Herston - The Royal Brisbane and Women's Hospital Cancer Centre (1)
6150 - Murdoch - Fiona Stanley Hospital (1)
Cancer Type
Cancer
Solid tumour
Lung cancer
Non-small cell lung cancer
Respiratory tract cancer
Thoracic cancer
Exocrine pancreatic cancer
Gastrointestinal cancer
Pancreatic adenocarcinoma
Pancreatic cancer
Pancreatobiliary cancer
Upper gastrointestinal cancer
MTAP:deletion
Haematological malignancy
Lymphoma
Non-Hodgkin's lymphoma
Peripheral T-cell lymphoma
T-cell lymphoma
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